What Does ceesdekker.net Mean?
What Does ceesdekker.net Mean?
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Working with solitary-molecule optical and AFM imaging and drive-spectroscopy procedures, we search for to unravel the mechanistic aspects of the composition and dynamics of chromosomes. Our investigation pursuits involve:
Human Rad51 filaments on double- and one-stranded DNA: correlating regular and irregular kinds with recombination functionality.
Multicolor imaging on the bacterial nucleoid and cell division proteins with blue, orange, and near-infrared fluorescent proteins
Our work was swiftly followed up by Other individuals, most notably by Phaedon Avouris and colleagues at IBM, who in October 1998 revealed their results on transistors made out of solitary- and multi-walled carbon nanotubes in Utilized Physics Letters.
This yielded a breakthrough. Inside of only some months, we ended up in a position to evaluate transport by a person one-walled carbon nanotube. According to small-temperature experiments by an excellent PhD university student in my group, Sander Tans (now a valued colleague and professor at Delft College of Technologies by having an active investigation lab at AMOLF in Amsterdam), we confirmed that carbon nanotubes have been legitimate quantum wires with extremely very long (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic conduct.
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of a single wire bridging two electrodes
What distinguishes biology from chemistry is usually that these elements together make up a residing system. The key of said daily life, I think, lies from the interactions, the interplay of Those people molecules. The big problem in regards to the origin of lifestyle remains to be unanswered. How did we at any time evolve from easy molecules in the very advanced systems we see nowadays? We do not know. I want to work on These types of big, open inquiries.’
Nanopores symbolize an elegant and flexible Device to measure single molecules. We analysis novel detection modes with strong-state nanopores in addition to numerous ways to evaluate proteins with nanopores. Jobs encompass the subsequent:
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Bulk-surface coupling identifies the mechanistic connection among Min-protein designs in vivo As well as in vitro
‘The concept there is such a point for a commencing, a big bang, is currently an interesting signpost to take into consideration that there was a creator. But extra usually, and on the basis of pure rationality, I also arrive at a Christian interpretation of actuality. An atheistic worldview can be a naturalistic worldview: basically, you will discover only atoms and purely natural forces that we can measure.
2006, initial demonstration of molecular sorting in the lab with a chip utilizing biomotors; discovery of nanobubbles in reliable-condition nanopores; and to start with estimate of electrokinetic Vitality conversion in a very nanofluidic channel
Enable’s first appear back in the meanwhile any time you made a decision to change your concentration from superconductivity and nanotubes to biology at the conclusion of the nineteen nineties.
2004, discovery of recent physics ceesdekker in translocation of DNA by way of nanopores; initial experimental analyze of ions conduction in nanofluidic channels; initially electrochemistry with personal one-wall carbon nanotubes; STM detection and control of phonons in carbon nanotubes; first electrical docking of microtubules on kinesin-coated nanostructures; initially biophysics characterization in the mechanical Attributes of double-stranded RNA; and 1st single-molecule review of DNA translocation by a restriction-modification enzyme.